Propofol - 2
Physicochemical Considerations
2,6-diisopropylphenol
SAR: increasing length of 2,6 side chains up to about 7 or 8 C atoms:
- increased sleep time
- increased potency
- decreased induction time
- decreased potency
- slower induction
- prolonged recovery
Present form:
- 20 ml amps or 50 ml vials:
- propofol 1%
- soybean oil 10%
- glycerol 2.25%
- egg phosphatide 1.2%
- pH 7-8
- isotonic
- no antimicrobial preservatives
- compatible with D5W