Ketamine - 4
Pharmacokinetics
- plasma disappearance fits a 2-compartment model
- t1/2(distribution) = 11 - 16 minutes
- Vdss = 3 L/kg (very lipid soluble)
- clearance (Cl) = 12 - 17 ml/kg/min
- t1/2(elimination) = 2 - 3 hours
Plasma levels needed for hypnosis and amnesia during surgery are approximately 0.7 to 2.2 mcg/ml (perhaps up to 4.0 mcg/ml in children). Awakening occurs below 0.5 mcg/ml.
