Ketamine - 2
Chemistry
Ketamine is2-(o-chlorophenyl)-2-(methylamino) cyclohexanone (hydrochloride):
In 3 dimensions:
Rotatable 3D model (download free MDL Chime plug-in to view):
Ketamine has a chiral center and is presently marketed as the racemic mixture of its two (mirror-image) enantiomers or enantiomorphs:
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| S-(+)-ketamine | R-(-)-ketamine |
Ketamine, molecular weight 238, is partially water soluble at pH 7.4 (pKa 7.5), and 5 to 10 times more lipid soluble than thiopental.
The commercial preparation (Ketalar) is a racemic mixture of (SR)-ketamine in NaCl solution with pH 3.5 to 5.5 and is prepared in three concentrations of ketamine: 10, 50 and 100 mg/ml, with benzethonium chloride added as a preservative.